ReviewFrontiers in cell and developmental biology2025
Advancements in mesenchymal stem cell therapy for chronic wounds: challenges, innovations, and future directions.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stem cell and extracellular vesicle therapies for wound healing: An umbrella review of predominantly diabetic and preclinical evidence.Cell transplantationPooled it
- Ultradeformable Vesicles for Wound Healing: Ethosomes, Transferosomes, and Transethosomes in Topical Drug Delivery.Pharmaceutics · 2026Review
- Stem cell-derived secretome: a novel strategy for wound healing.Frontiers in pharmacology · 2026Review
- Advancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategies.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of chronic wounds remains challenging due to their complex pathophysiology, poor response to conventional therapies, and significant impact on patients' quality of life. mesenchymal stem cells (MSCs) have garnered attention as a potential treatment due to their regenerative and immunomodulatory properties. This review summarizes preclinical and clinical advancements in MSC-based therapies for chronic wound healing. MSCs promote tissue regeneration through various mechanisms, including differentiation into skin cell lineages, modulation of inflammation, angiogenesis, and paracrine release of bioactive factors. Current research focuses on identifying viable MSC sources, optimizing delivery methods, and understanding their mechanisms for clinical use. Despite progress, challenges remain, including inconsistent results, poor MSC survival in the wound microenvironment, and variability in regenerative capacity across MSC sources. Future research should focus on developing standardized guidelines for MSC preparation and conducting long-term randomized trials to assess safety, efficacy, and potential risks. In conclusion, this review highlights current evidence and identifies key challenges for the clinical application of MSCs in chronic wound healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.