Evidence map›Paper›PMID 41602824›Full record

ArticleFrontiers in cell and developmental biology2025

De novo assembly and single-molecule study of kinetochore-microtubule interactions.

Joshua D Larson, Lillian R Worst, Charles L Asbury

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joshua D LarsonDepartment of Neurobiology & Biophysics, University of Washington, Seattle, WA, United States.
Lillian R WorstDepartment of Neurobiology & Biophysics, University of Washington, Seattle, WA, United States.
Charles L AsburyDepartment of Neurobiology & Biophysics, University of Washington, Seattle, WA, United States.

Funding

Reconstitution and biophysical study of chromosome segregation machineryR35GM134842 · NIGMS · UNIVERSITY OF WASHINGTON · PI Charles L Asbury · 2020 to 2026
$4.7M
Molecular Biophysics Training ProgramT32GM153507 · NIGMS · UNIVERSITY OF WASHINGTON · PI Charles L Asbury, Justin M Kollman · 2024 to 2026
$1.7M
NIGMS NIH HHS R35 GM134842NIGMS NIH HHS T32 GM153507
6 · The paper itself

Abstract

Kinetochores are essential molecular machines composed of dozens of protein subcomplexes that assemble onto specialized centromeric nucleosomes during every cell cycle prior to mitosis. During mitosis, the assembled kinetochores are responsible for maintaining load-bearing attachments to dynamic spindle microtubules, and for harnessing the forces generated by attached microtubules to organize and separate sister chromatids. Recent work shows that kinetochores can be reconstituted by assembling them

Indexed as

cell divisionmicrotubule polaritymitosismitotic spindleplus end preferenceTIRF microscopy

Identifiers

PMID41602824
PMCPMC12833015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.