Evidence map›Paper›PMID 41602823›Full record

ReviewFrontiers in cell and developmental biology2025

Notch signaling pathway modulation by food functional ingredients: mechanisms, cancer and immunoregulation.

Rong-Zu Nie, Huo-Min Luo, Ya-Ping Liu, Shuang-Shuang Wang, Yan-Jie Hou, Chen Chen, Hang Wang, Hui-Lin Lv, Xing-Yue Tao, Zhao-Hui Jing and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rong-Zu NieCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Huo-Min LuoCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Ya-Ping LiuCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Shuang-Shuang WangCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Yan-Jie HouCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Chen ChenCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Hang WangCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Hui-Lin LvCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Xing-Yue TaoCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Zhao-Hui JingCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Hao-Kun ZhangCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Pei-Feng LiCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article comprehensively reviews the complex role of the Notch signaling cascade in cancer, as well as the regulatory mechanisms and potential anti-cancer effects of food functional ingredients on this pathway. The Notch signaling cascade is essential for maintaining normal cellular physiological processes and is closely associated with cancer initiation and progression; its abnormalities are linked to diverse biological behaviors of tumor cells, and it exhibits dual roles in both pro-cancer and anti-cancer properties. Food functional ingredients, including polyphenols, terpenoids, sulfur-containing compounds, vitamins, minerals, and other compounds, can precisely regulate the Notch signaling pathway

Indexed as

anti-cancer mechanismcancer treatmentfood functional ingredientsimmunomodulationnotch signaling

Identifiers

PMID41602823
PMCPMC12832682

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.