ArticleACS applied nano materials2025
Antitumor Efficacy and Immunomodulation of H‑Ferritin Nanocaged Doxorubicin for Triple Negative Breast Cancer.
Article in ACS applied nano materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Latest advances in nanodrug delivery systems for modulating the immune microenvironment in triple-negative breast cancer.Frontiers in immunology · 2026Review
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Authors and funding
14 authors.
Funding
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Abstract
Triple-negative breast cancer (TNBC) remains a major therapeutic challenge due to its aggressiveness and lack of targeted treatment options. Ferritin-encapsulated doxorubicin (HFn-Dox) is a nanocarrier-based formulation with documented tumor targeting activity and antitumor potential. In this study, we advance its clinical relevance by evaluating the HFn-Dox efficacy and toxicity profile at therapeutic dosing in patient-derived xenograft (PDX) and syngeneic TNBC models. HFn-Dox significantly outperformed free Dox by suppressing tumor growth and reducing metastatic spreading in both the models. When compared with free Dox and the clinically approved pegylated liposomal doxorubicin (Lipo-Dox), HFn-Dox also displayed a more favorable cardiotoxicity profile, which allowed dose intensification without compromising safety. Additionally, HFn-Dox modulated the tumor immune microenvironment in immunocompetent mice by enhancing intratumoral infiltration of Tlymphocytes and M1 macrophage polarization. In vitro, HFn-Dox preserved the T cell viability and prevented exhaustion. It also promoted the activation of macrophages and dendritic cells, contrasting with the immunosuppressive effects of free Dox. Altogether, our results demonstrate that HFn-Dox can increase the therapeutic index of doxorubicin by combining improved tumor delivery, reduced off-target toxicity, and immune system preservation. These features support the translational potential of HFn-Dox as a safer and more effective nanochemotherapy for TNBC.
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