Enhancing implant surfaces: mechanical stability and cytocompatibility of DNase I coatings deposited by alternating current electrophoretic deposition.

Merve Kübra Aktan, Naiera Zayed, Aydan Yadigarli, Manuela Sonja Killian, Rob Lavigne, Wim Teughels, Annabel Braem

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Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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0 citing papers in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Merve Kübra AktanBiomaterials and Tissue Engineering Research Group, Department of Materials Engineering (MTM), KU Leuven, Leuven, Belgium.

Naiera ZayedDepartment of Oral Health Sciences, Faculty of Medicine, KU Leuven, Leuven, Belgium.

Aydan YadigarliChemistry and Structure of Novel Materials, University of Siegen, Siegen, Germany.

Manuela Sonja KillianChemistry and Structure of Novel Materials, University of Siegen, Siegen, Germany.

Rob LavigneLaboratory of Gene Technology, Department of Biosystems, KU Leuven, Leuven, Belgium.

Wim TeughelsDepartment of Oral Health Sciences, Faculty of Medicine, KU Leuven, Leuven, Belgium.

Annabel BraemBiomaterials and Tissue Engineering Research Group, Department of Materials Engineering (MTM), KU Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deoxyribonuclease I (DNase I) is an enzyme that hydrolyzes the phosphodiester bonds in the DNA backbone, enabling efficient DNA degradation. This activity is particularly relevant for degrading extracellular DNA (eDNA), a key structural component of the biofilm extracellular matrix that enhances bacterial attachment to implant surfaces and promotes cell-to-cell adhesion. By disrupting this matrix, DNase I offers significant potential to indirectly inhibit biofilm formation and reduce the risk of implant-associated infections (IAIs). In previous work, we developed a rapid electric field-assisted technique for producing anti-infective DNase I coatings on titanium (Ti) implant surfaces. To further evaluate clinical applicability, this study investigates the mechanical stability and

Indexed as

coatingscytocompatibilitydeoxyribonuclease (DNase)electrophoretic deposition (EPD)mechanical stability

Identifiers

PMID41602476

DOI10.3389/fbioe.2025.1738602

PMCPMC12832641

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.