ArticleFrontiers in bioengineering and biotechnology2025
Uneven effects of trans-vaginal mesh reconstruction on the viscoelastic property of the urinary bladder in patients with pelvic organ prolapse.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05682989 (Evaluation of Efficacy and Safety of Urogynecology Synthetic Mesh Surgery in Women With Pelvic Organ Prolapse), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Efficacy and Safety of Urogynecology Synthetic Mesh Surgery in Women With Pelvic Organ Prolapse
Who cites it
1 citing paper in PubMed.
- Changes of bladder urodynamics after combined pelvic floor muscle training and intravaginal stimulation in women with stress urinary incontinence: a retrospective cohort study.Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The pathophysiology underlying deficits in bladder storage and possible rationale for how transvaginal mesh (TVM) reconstruction benefits bladder function in patients with pelvic organ prolapse (POP) remain unclear. Compliance, a viscoelastic parameter, crucially characterizes the bladder's storage function. Pressure-volume analysis (PVA) has been recently applied to specifically assess compliance dynamics during different stages of bladder filling. This study investigated compliance dynamics in patients with POP using PVA and analyzed the impact of TVM on bladder compliance. Methods: PVAs were retrospectively constructed by plotting intravesical volume (Vive) against detrusor pressure (Pdet) in patients with POP undergoing TVM repair. Parameters analyzed included mean compliance during the entire, early, and late halves of bladder filling (Cm, C1/2, and C2/2, respectively); infused volume (Vinf); threshold pressure (Pthd); Pdet changes in the early and late filling (ΔPthd1/2 and ΔPthd2/2, respectively); post-void residual volume (Vres); and ultrasound imaging. Results: Before TVM, patients exhibited significantly lower C2/2 than C1/2 (p < 0.001, N = 22), while postoperatively, no significant difference was observed between C2/2 and C1/2 (p = 0.102, N = 22). TVM significantly increased Cm (p = 0.004, N = 22) and C2/2 (p < 0.001, N = 22) but had no significant effect on C1/2 (p = 0.572, N = 22). Postoperatively, Pthd (p = 0.001, N = 22) and ΔPthd2/2 (p = 0.001, N = 22) were significantly reduced, while ΔPthd1/2 (p = 0.084, N = 22) and Vinf (p = 0.112, N = 22) remained unaffected. Ultrasound imaging demonstrated that TVM relieved restrictions on bladder expansion during late filling. Discussion: Patients with POP showed heterogeneous compliance deficits, particularly during late bladder filling. TVM selectively improved compliance impairment possibly by restoring anatomical geometry for bladder expansion. Clinical Trial Registration: ClinicalTrials.gov (NCT05682989).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.