Evidence map›Paper›PMID 41602453›Full record

ArticleFrontiers in physiology2025

Exploring the physiological limits of aging: a case study of the male 50-km world record in the 80+ age category.

A M Pilotto, E Higueras-Liébana, M Ansaldo, I Baltasar-Fernandez, M Neri, L Giusti, Á Buendía-Romero, P L Valenzuela, J Alcazar, F Lauretani and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

A M Pilotto *Department of Molecular Medicine, University of Pavia, Pavia, Italy.
E Higueras-Liébana *GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.
M AnsaldoDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
I Baltasar-FernandezGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.
M NeriDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
L GiustiDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Á Buendía-RomeroGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.
P L ValenzuelaGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.
J AlcazarGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.
F LauretaniGeriatric Clinic Unit, Medical Geriatric Rehabilitative Department, University Hospital of Parma, Parma, Italy.
R ReDepartment of Physics, Politecnico di Milano, Milano, Italy.
A BotterDepartment of Electronics and Telecommunications, Laboratory for Engineering of the Neuromuscular System (LISiN), Politecnico di Torino, Torino, Italy.
M V FranchiDepartment of Biomedical Sciences, University of Padova (UNIPD), Padova, Italy.
I AraGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.
S PorcelliDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with declines in cardiorespiratory fitness and endurance performance, but this association is usually confounded by age-related declines in physical activity levels. For this reason, world-class master athletes serve as exceptional models for elucidating the limits of endurance performance in old age. Purpose: To examine the physiological responses to exercise and performance characteristics of an 81-year-old male runner who, in 2025, set a new world record in the 50-km race (4h47m39s, 10.5 km h Methods: Two weeks after the world record, maximal O Results: Conclusion: The exceptional endurance performance of this master athlete was attributed to his well-preserved

Indexed as

agingmaximal oxygen consumptionNIRSrunningwagner diagram

Identifiers

PMID41602453
PMCPMC12832481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.