ReviewFrontiers in oncology2025
HPV, APOBEC3B, and the origins of breast cancer: a narrative review and perspectives on novel mechanisms.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16Exploration of targeted anti-tumor therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is one of the most severe global health challenges, with its incidence continuing to rise. The development of this malignancy is associated with numerous risk factors; however, its primary etiology often remains unclear. Research on the potential association between breast cancer and carcinogenic human papillomavirus (HPV) has been conducted for three decades, yet a definitive consensus has not been reached. The development of prophylactic cervical cancer vaccines has greatly heightened the urgency of this issue: if a causal relationship can be established, it would open a feasible avenue for preventing this common cancer. This review aims to systematically integrate relevant evidence and provide a critical commentary on the association between HPV and breast cancer. We analyzed evidence from 34 studies on HPV DNA detection in breast cancer cells. We discuss the prevalence and genotypes of HPV detected in breast cancer across different geographical regions, the state of the viral genome (integrated vs. episomal), viral load, and potential mechanisms for HPV-associated breast carcinogenesis-particularly its role in inducing genomic instability via activation of APOBEC3B. Additionally, we explore the histopathological and clinical characteristics of HPV-positive breast cancer. The synthesized evidence suggests that high-risk HPV types are present in a subset of breast cancers worldwide, but with lower viral loads compared to cervical cancer, indicating a potentially different mode of action. The association between HPV and breast cancer warrants further rigorous investigation to clarify its clinical and preventive implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.