Evidence map›Paper›PMID 41602389›Full record

ReviewFrontiers in oncology2025

Liquid biopsy in triple-negative breast cancer: a promising tool for diagnosis, prognosis, and treatment monitoring.

Marianna Rita Brogna, Gerardo Ferrara, Valeria Varone, Angela Montone, Adriana Fava, Maria Rosaria Schiano, Michele Del Sesto, Nubia Pizza, Annalisa Prota, Carmela Barra and 1 more

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marianna Rita BrognaPathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Gerardo FerraraPathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Valeria VaronePathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Angela MontonePathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Adriana FavaPathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Maria Rosaria SchianoPathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Michele Del SestoPathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Nubia PizzaPathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Annalisa ProtaPathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Carmela BarraPathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.
Francesca CollinaPathology Unit, Istituto Nazionale Tumori-Istituto Di Ricerca E Cura A Carattere Scientifico (IRCCS)-Fondazione G. Pascale, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous subtype of breast cancer, characterized by poor prognosis and limited treatment options. With the advancements in precision oncology, liquid biopsy has emerged as a promising, non-invasive tool for diagnosing TNBC, predicting prognosis, and monitoring treatment response. Circulating tumor DNA (ctDNA) and other biomarkers, such as circulating tumor cells (CTCs), exosomal RNA, and non-coding RNAs, offer valuable insights into tumor heterogeneity, disease progression, and therapeutic efficacy. Recent research has indicated that the presence of ctDNA following neoadjuvant chemotherapy is associated with reduced progression-free survival. Additionally, mutations in key genes such as

Indexed as

circulating tumor cells (CTCs)circulating tumor DNA (ctDNA)liquid biopsyprecision oncologytreatment responsetriple-negative breast cancer (TNBC)

Identifiers

PMID41602389
PMCPMC12832448

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.