ArticleFrontiers in oncology2025
Efficacy and safety of transarterial chemoembolization combined with sintilimab and bevacizumab in hepatocellular carcinoma.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Transarterial chemoembolization (TACE) is standard of care for patients with unresectable hepatocellular carcinoma (uHCC) that is amenable to embolization; however, its long-term prognosis is limited. Recently, TACE with systemic therapies showed meaningful improvement in clinical outcomes. This study aims to evaluate the real-world efficacy and safety of transarterial chemoembolization (TACE) combined with sintilimab and a bevacizumab biosimilar in the treatment of unresectable hepatocellular carcinoma (uHCC), which has been incorporated into the first-line treatment regimen in China. Methods: A retrospective analysis was conducted on 60 patients with uHCC who received TACE combined with sintilimab (200mg IV, q3w) and a bevacizumab biosimilar (15mg/kg IV, q3w) at Ganzhou People's Hospital from August 2019 to June 2024, with follow-up until June 30, 2025. Overall survival (OS), progression-free survival (PFS), post-treatment tumor response, and treatment-related adverse events (tr-AEs) were recorded and analyzed. Use Kaplan-Meier for survival and Cox model for risk factors. Results: A total of 60 patients were enrolled in this study. The median OS was 24.0 months, and the median PFS was 13.0 months. According to the Response Evaluation Criteria in Solid Tumors (RECIST) v1.1, the best overall response rate (ORR) was 35.0%, and the disease control rate (DCR) was 91.7%. Based on the modified RECIST (mRECIST) criteria, the best ORR and DCR were 83.3% and 91.7%, respectively. Multivariate analysis identified macrovascular invasion as an independent risk factor for both OS and PFS (P < 0.05). All tr-AEs were manageable, and no treatment-related deaths occurred. Conclusion: TACE plus sintilimab-bevacizumab biosimilar has favorable efficacy and manageable safety in patients with uHCC, supporting its use as a treatment option in HCC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.