ArticleFrontiers in cardiovascular medicine2025
Myocarditis with preserved left ventricular ejection fraction in-hospital convalescent phase: insights from CMR and myocardial strain analysis.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The convalescent phase of myocarditis in patients with preserved left ventricular ejection fraction remains poorly characterized. Persistent myocardial inflammation may elevate the risk of major adverse cardiovascular events (MACE). Conventional assessment of left ventricular function is limited in sensitivity, whereas myocardial strain analysis provides detection of subclinical myocardial dysfunction. Methods: In this retrospective study, 317 patients with myocarditis underwent cardiac magnetic resonance (CMR). Feature-tracking CMR was used to quantify ventricular and atrial strain parameters. Late gadolinium enhancement (LGE) was assessed for myocardial tissue characterization. Patients were followed clinically, with MACE as the primary endpoint. Results: Among 146 patients included in the final analysis (71 male; mean age 26 ± 16 years), 36 experienced MACE. LGE was present in 54.8% of patients. In LGE positive patients, one, two, and three or more segments were involved in 6.25%, 16.25%, and 77.50% of cases, respectively. In univariable and multivariable Cox regression analyses, left ventricular global radial strain ( Conclusions: Left ventricular global radial strain may reflect persistent myocardial inflammation during convalescence from myocarditis. Myocardial strain parameters provide incremental prognostic value beyond conventional functional measures.
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