Evidence map›Paper›PMID 41602224›Full record

ReviewCureus2025

The Role of Natural Orifice Specimen Extraction in Modern Surgery: A Narrative Review.

Mark Salib, John Salib, Murali K Manikkavelu, Timothy J Stear

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mark SalibMedicine, St. George's University School of Medicine, St. George's, GRD.
John SalibMedicine, St. George's University School of Medicine, St. George's, GRD.
Murali K ManikkaveluGeneral Surgery, Community First Medical Center, Chicago, USA.
Timothy J StearGeneral Surgery, Community First Medical Center, Chicago, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural Orifice Specimen Extraction (NOSE) is an innovative, minimally invasive technique that combines laparoscopic or robotic resection with specimen retrieval through natural orifices, eliminating the need for abdominal extraction incisions. By avoiding additional incisions, NOSE reduces postoperative pain, wound complications, and recovery time, while preserving oncologic integrity. It has been widely applied in colorectal and gynecologic procedures, demonstrating feasibility, safety, and improved patient-centered outcomes. This review synthesizes current evidence on surgical indications, technical considerations, postoperative recovery, complications, oncologic outcomes, and patient-reported metrics. Robotic-assisted NOSE is also discussed as a means to overcome anatomical challenges and expand procedural applicability. Despite promising results, gaps remain in long-term functional outcomes, standardized protocols, and economic analyses. Continued research is needed to refine techniques, broaden indications, and optimize patient outcomes. NOSE represents a transformative approach within minimally invasive surgery, potentially improving recovery, satisfaction, and overall surgical quality.

Indexed as

laparoscopic surgeryminimally invasive surgerynatural orifice specimen extractionnosenose surgeryspecimen extraction routespecimen retrievaltransgastric specimen extractiontransrectal specimen extractiontransvaginal specimen extraction

Identifiers

PMID41602224
PMCPMC12834528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.