Evidence map›Paper›PMID 41602155›Full record

ReviewFrontiers in molecular neuroscience2025

Structure and function of neurovascular unit in arterial hypertension.

Ewa Kozniewska, Marta Aleksandrowicz

Abstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ewa KozniewskaLaboratory of Preclinical Research and Environmental Agents, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Marta AleksandrowiczLaboratory of Preclinical Research and Environmental Agents, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arterial hypertension is considered a main risk factor for cognitive impairment and stroke. Although chronic hypertension leads to adaptive changes in the lager cerebral blood vessels which should protect the downstream microvessels, profound changes in the structure and function of cerebral microcirculation were reported in this disease. The structural changes lead to dysregulation of the neurovascular unit and manifest themselves in particular as endothelial dysfunction, disruption of the blood-brain barrier and impairment of neurovascular coupling. The impairment of neurovascular coupling results in inadequate functional hyperemia, which in turn may lead to cognitive decline and dementia. In this review the effects of chronic arterial hypertension on the essential components of neurovascular unit involved in neurovascular coupling such as endothelial cells, astrocytes and pericytes are discussed.

Indexed as

astrocytesendothelial glycocalyxendotheliumglymphatic systemhypertensionneurovascular couplingpericytes

Identifiers

PMID41602155
PMCPMC12833352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.