ReviewFrontiers in cellular and infection microbiology2025
Lactate and lactylation in macrophage polarization of sepsis.
Review in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Lactate in ruminant health: metabolic roles and the emerging significance of lactylation.Journal of animal science and biotechnology · 2026Review
- Lactylation in sepsis-associated acute kidney injury: regulatory mechanisms and therapeutic prospects.Frontiers in molecular biosciences · 2026Review
- Metabolite-driven protein modifications in immune signaling: from established principles to emerging pyruvylation.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis, which is characterized by potentially fatal multiple organ dysfunction, is caused by an abnormal host response to a major infection. During sepsis, the pathogen stimulates the host to activate resistance mechanisms that enhance immune cells' oxygen consumption in inflammatory tissues and cells, and promote aerobic glycolysis. Lactate generated by aerobic glycolysis is an essential substrate for the tricarboxylic acid cycle and for post-translational modifications via histone lactylation and epigenetic regulation. It also serves as a signaling molecule that modulates macrophage polarization between pro- and anti-inflammatory phenotypes in response to inflammatory and metabolic signals in their local environment. The roles of lactate and lactylation modifications in cancer cell proliferation and invasion have been well studied and are now potential therapeutic targets for various malignancies. However, the roles of lactate and lactylation modification in sepsis remain unclear. This review focuses on lactate's regulatory mechanism and lactylation modification during macrophage polarization in sepsis, and investigates whether this regulation could be a potential therapeutic target for sepsis.
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Registered trials
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