ArticleFrontiers in public health2025
Association between HALP score and in-hospital mortality in sepsis patients: a multicenter retrospective cohort study with external validation.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Admission CRP as an Independent Predictor of Prolonged Length of Stay in Calculous Acute Pyelonephritis: A Comparative Evaluation With the HALP Score.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Association of the Modified HALP Score with Disease Complexity in Deep Neck Infections: A Dual-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
- Prognostic Value of the Preoperative HALP Score for Survival in Non-Malignant Liver Transplant Recipients.Journal of clinical medicine · 2026Article
- Comparative predictive performance of HALP score and prognostic nutritional index for mortality in ICU patients after hip fracture surgery.BMC geriatrics · 2026Article
- Comparative Prognostic Performance of HALP, PIV, and Naples Prognostic Score in Critically Ill Patients with Sepsis: A Retrospective Multicentre Cohort Study.Journal of clinical medicine · 2026Article
- Hematological Inflammatory Indices and the HALP Score for Pathogen Differentiation in Culture-Proven Late-Onset Neonatal Sepsis.Children (Basel, Switzerland) · 2026Article
- Low hemoglobin-albumin-lymphocyte-platelet score as a risk marker for stroke-associated pneumonia in acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The HALP (Hemoglobin, Albumin, Lymphocyte, and Platelet) score integrates key parameters reflecting nutritional and immune status. However, its prognostic value for in-hospital mortality in sepsis patients remains underexplored. Objective: To investigate the association between HALP score and in-hospital mortality in sepsis patients using two large critical care databases. Methods: We conducted a retrospective cohort study including adult patients with Sepsis-3 from the eICU Collaborative Research Database (derivation cohort, Results: A total of 16,625 patients were analyzed. RCS analysis demonstrated significant nonlinear associations between HALP and in-hospital mortality in both cohorts (overall Conclusion: The HALP score demonstrates robust prognostic value for predicting in-hospital mortality in sepsis patients, with consistent nonlinear relationships validated across two large databases. Its simplicity and reliance on routine laboratory parameters support potential clinical application in sepsis risk stratification.
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Registered trials
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