ArticleFrontiers in pharmacology2025
Assessment of the acute toxicity of ethanol extract from the rhizomes of
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Development, Physicochemical Characterization, and Biological Activity of a Gel Based onMolecules (Basel, Switzerland) · 2026Article
- Phylogenomics, divergence time estimation, and biogeography ofFrontiers in plant science · 2026Article
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9 authors.
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Abstract
Background: Plants of the genus Aim: The aim of this study was to evaluate the acute oral toxicity of ultrasonic ethanol extract of Methods: The extract was administered once intragastrically at doses of 500, 1000, and 2000 mg/kg, followed by 14 days of observation of clinical status, body weight dynamics, hematological, biochemical, and histomorphological parameters. Results: No fatalities were recorded. Blood parameters remained within physiological norms (p > 0.05). At the maximum dose, a slight, statistically insignificant increase in ALT and AST activity was observed, reflecting a compensatory response of hepatocytes without signs of cytolysis. Histopathological analysis revealed moderate reversible changes in renal tissue, characterized by vacuolization of the tubular epithelium, venous hyperemia, and mild inflammatory infiltration, while maintaining normal glomerular structure and absence of fibrosis. The morphology of the liver, pancreas, heart, and spleen remained unchanged. Conclusion: According to the OECD/GHS classification,
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