ReviewFrontiers in endocrinology2025
The adrenal gland and primary aldosteronism: anatomy, steroidogenesis, regulation, and genetic insights.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Familial Hyperaldosteronism Type IV (FH-IV)-Clinical Phenotypes, Genetics and Management ofJournal of clinical medicine · 2026Review
- Subclinical primary aldosteronism: toward a conceptual framework linking primary aldosteronism and low-renin hypertension.Frontiers in endocrinology · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adrenal glands play an essential role in maintaining homeostasis through the secretion of steroid hormones. Among these, aldosterone, a mineralocorticoid produced in the zona glomerulosa (ZG) of the adrenal cortex, regulates fluid balance and blood pressure. This review summarizes the current knowledge of adrenal anatomy, aldosterone biosynthesis and regulation, and the pathophysiology and genetic landscape of primary aldosteronism (PA), a common form of secondary hypertension. Advances in next-generation sequencing have enabled the discovery of novel somatic and germline mutations underlying PA, elucidating their roles in abnormal aldosterone production and adrenal cell proliferation. Understanding the molecular basis of aldosterone dysregulation provides critical insights into PA subtypes, informing the development of improved diagnostic and therapeutic strategies.
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