ArticleFrontiers in endocrinology2025
The role of dopamine release and D2 dopamine receptor in GHRH and somatostatin cells in controlling growth hormone secretion.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Effects of Cysteamine Zinc Supplementation on Blood Hormones, Intestinal Flora, and Metabolites in Lactating Mares.Animals : an open access journal from MDPI · 2026Article
- Long-acting growth hormone therapy in paediatric growth hormone deficiency: reduced treatment burden and unproven motivation-related neuroendocrine effects.Frontiers in endocrinology · 2026Review
- Proteoformics-driven new concept of human growth hormone in clinical endocrinology.Frontiers in endocrinology · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Pituitary growth hormone (GH) secretion is primarily controlled by GH-releasing hormone (GHRH) and somatostatin (SST), peptides produced by hypothalamic neurons. Evidence indicates that dopamine also modulates GH secretion, potentially via D2 dopamine receptor (D2R). Additionally, a subset of GHRH neurons in the arcuate nucleus of the hypothalamus expresses tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine biosynthesis. However, the role of dopamine release from GHRH neurons and the neuronal population that expresses D2R to regulate GH secretion remain currently unknown. Methods: Mice lacking TH specifically in GHRH cells were generated. Results: GHRH Discussion: Dopamine production in GHRH neurons is not necessary for regulating body growth or GH secretion. D2R ablation in GHRH or SST neurons has a small impact on lean mass and GH secretion, indicating that these neurons mediate only a minor part of the effects induced by complete D2R absence in male mice.
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