ArticleFrontiers in nutrition2025
Immune response in breastmilk of Black women to SARS-CoV-2 infection and vaccination against COVID-19.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Introduction: In the United States, Black lactating women are underrepresented in health-related studies. This underrepresentation is a concern when interpreting results from studies of the immune response to SARS-CoV-2 in breastmilk because we know that individuals vary greatly in their response to both infection and vaccination. Additionally, few studies of the immune response in human milk include analysis of mammary epithelium permeability, despite the knowledge that elevated permeability can alter constituents in milk. To address these gaps, we enrolled local Black breastfeeding mothers during a 3-day breastfeeding conference in New Orleans to assess the immune response in milk to infection or vaccination with SARS-CoV-2. Materials and methods: 3 weeks prior to the ROSE Black Breastfeeding & Birth Justice Summit of 25-27 August 2022, we advertised for " Results: Among the 16 lactating women who provided samples, 8 had a positive COVID-19 test within the previous 19 months, and 12 had received an mRNA-based COVID-19 vaccine within the previous 16 months. Milk and maternal blood spots from all participants were positive for all anti-SARS-CoV-2 antibody classes tested, while only a subset of saliva samples were positive for all anti-SARS-CoV-2 antibody classes. A significant correlation was found between mammary epithelium permeability and concentrations of IL-1β, IL-6, and IL-8 cytokines. Conclusion: Results from this small pilot study supported the need to include a diverse population in breastmilk studies, as the immune response in milk varied greatly among individuals. Future studies assessing the response to infections and vaccinations in lactating women should include analysis of milk from both breasts, as well as assessment of mammary epithelium permeability.
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