ArticleFrontiers in nutrition2025
Exploring the potential association between dietary factors and autism spectrum disorder: a Mendelian randomization analysis and retrospective study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition involving complex genetic and environmental interactions. This study aimed to investigate the causal relationships between dietary factors, ketones, food allergy, and the risk of ASD using Mendelian randomization (MR) and clinical research. Methods: We used two-sample MR to analyze the causal associations between 199 dietary factors, ketones, food allergy, and ASD risk using genome-wide association study (GWAS) data. Validity was assessed using sensitivity analyses. Additionally, a retrospective study ( Results: MR analysis identified significant positive causal effects on ASD risk for wholemeal pasta (OR: 16.0, 95% CI 2.86-89.4, Conclusion: This study provides genetic evidence of causal relationships between specific dietary factors and ASD risk. Clinical data indicate that adhering to a gluten-free, casein-free diet and avoiding related allergenic foods can effectively modulate food-specific immune responses and may also improve ASD symptoms. These findings contribute to deepening our understanding of ASD etiology and optimizing nutritional treatment protocols.
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