Evidence map›Paper›PMID 41601897›Full record

ReviewFrontiers in nutrition2025

Nanoencapsulation of nutraceuticals: enhancing stability and bioavailability in functional foods.

Minglu Hao, Xiaonan Tan, Kang Liu, Ning Xin

Abstract readReview
In one paragraph

Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Optimization and Metabolomic Profiling ofInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. O-methylation of phenolic natural products: translational insights from resveratrol.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Nano-Enabled Advances in Tea Tree Essential Oil (Materials (Basel, Switzerland) · 2026
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Minglu HaoQingdao Hengxing University of Science and Technology, Qingdao, China.
Xiaonan TanQingdao Hengxing University of Science and Technology, Qingdao, China.
Kang LiuQingdao Hengxing University of Science and Technology, Qingdao, China.
Ning XinQingdao Hengxing University of Science and Technology, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While nutraceuticals hold great promise for improving health, their efficacy is often limited by the poor stability and low bioavailability of many bioactive compounds. Nanoencapsulation has emerged as a transformative solution to these challenges, involving nanoscale carriers that protect sensitive nutrients from degradation and enhance their absorption. This review provides a comprehensive overview of nanoencapsulation strategies in the food and nutrition domain. We outline the historical development of key nanocarrier systems, from early liposomal delivery vehicles to advanced lipid nanoparticles, nanoemulsions, and biopolymer-based nanoparticles engineered for improved nutraceutical delivery. The physicochemical and biological mechanisms responsible for enhancing the performance of nanoencapsulation systems are systematically elucidated. Nanoencapsulation can shield bioactives from light, heat, oxidation, and pH extremes. It also improves oral bioavailability through enhanced solubility, controlled release, mucoadhesion, endocytosis-mediated uptake, and lymphatic transport that bypasses first-pass metabolism. Key examples of nanoencapsulated nutraceuticals in functional beverages, dairy products, dietary supplements, and other foods are highlighted, illustrating the growing commercial applications of food nanotechnology. We also discuss challenges related to manufacturing scale-up, safety and toxicology, regulatory oversight, and consumer acceptance of nano-enabled nutraceuticals, and we present emerging trends such as co-encapsulation of synergistic ingredients and precision nutrition approaches. By integrating advances in nanotechnology with nutritional science, nanoencapsulation is poised to significantly amplify the health benefits of functional foods and nutraceutical products in the coming years, paving the way for more effective functional diets and improved public health.

Indexed as

bioavailabilityfood nanotechnologyfunctional foodsnanocarriersnanoencapsulationnutraceuticals

Identifiers

PMID41601897
PMCPMC12832464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.