ArticleFrontiers in nutrition2025
A novel functional water significantly modulates the gut microbiota and decreases the basal level of inflammation in mice.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Accumulating evidence has identified the gut microbiota as a critical regulator of biological processes such as immune homeostasis, and its dysbiosis has been implicated in the pathogenesis of numerous diseases. Current strategies for modulating the gut microbiota remain limited by several challenges: low colonization efficiency (probiotics), interindividual variability in host response (prebiotics), and safety concerns (antibiotics). Methods: We investigated the effects of a physically processed, additive-free purified water (Koishio water, KW) on gut microbiota composition and basal inflammatory status in healthy mice. Results: First, KW drinking significantly increased the diversity and richness of the gut microbiota of the mice, including increased abundance of Verrocomicrobiota and decreased abundance of Proteobacteria; Second, KW drinking significantly increased the abundance of several beneficial genera of the gut bacterium ( Conclusion: These findings demonstrate that KW, characterized by affordability, safety, and suitability for daily consumption, may serve as a novel non-pharmacological intervention to beneficially modulate gut microbiota composition and reduce basal inflammatory levels under non-pathological conditions.
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