Evidence map›Paper›PMID 41601832›Full record

ArticleFrontiers in medicine2025

Investigation of the pharmacological mechanisms of Denglao Qingguan decoction in inhibiting viral pneumonia through network pharmacology and

Biao Lei, Shun Wang, Xuanxuan Li, Fang Chen, Wencong Lu, Bin Liu, Xiannan Chen, Ruihan Chen, Zhanyu Cui, Ai Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Biao Lei *Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Shun Wang *School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xuanxuan Li *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.
Fang Chen *Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Wencong LuGuangdong Women and Children Hospital, Guangzhou, Guangdong, China.
Bin LiuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xiannan ChenHospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Ruihan ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.
Zhanyu CuiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.
Ai LiBaiyun District Maternal and Child Health Hospital, Guangzhou, Guangdong, China.
Xi RenHospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Linzhong YuThird Level Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Qinhai MaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Respiratory viral infection poses a serious threat to human health, underscoring the need for effective agents to prevent and treat these conditions. Objective: This study aimed to investigate Denglao Qingguan decoction (DLQGD), a traditional formula used in the management of respiratory infections, and to elucidate its efficacy and mechanisms against viral pneumonia. Methods: Network pharmacology was employed to investigate the potential mechanism of DLQGD against viral pneumonia. The components of DLQGD were analyzed by High-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry (HPLC-Q-TOF MS). The antiviral effects of DLQGD against respiratory syncytial virus (RSV), influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were determined by cytopathic effect or MTT assays. The inhibitory effects of DLQGD on RSV or SARS-CoV-2-induced inflammatory response were determined by reverse transcriptase-quantitative PCR. Results: A total of 66 active ingredients were identified in DLQGD. Network pharmacology showed that DLQGD could regulate a total of 122 targets involved in viral pneumonia. The 50% inhibitory concentration (IC Conclusion: Collectively, these findings indicate that DLQGD exhibits antiviral and anti-inflammatory activities, suggesting that it could be developed into a therapeutic constituent for respiratory viral infections.

Indexed as

Denglao Qingguan decoctioninflammatory responseinfluenza virusrespiratory syncytial virussevere acute respiratory syndrome coronavirus 2traditional Chinese medicine

Identifiers

PMID41601832
PMCPMC12832263

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