ArticleFrontiers in medicine2025
Hemodynamic responses detected by exercise echocardiography in patients with ankylosing spondylitis and psoriatic arthritis.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Cardiopulmonary complications are common in ankylosing spondylitis (AS) and psoriatic arthritis (PsA) and have an adverse impact on the mortality and quality of life of patients. Myocardial involvement can lead to systolic and diastolic dysfunction, which can be asymptomatic for a long time. Chest wall rigidity, a complication of both diseases, can also lead to cardiac dysfunction, especially in the right heart-pulmonary circulation unit. We aimed to assess the response of the pulmonary circulation-right ventricular function unit and left ventricular function during exercise in AS and PsA patients and hypothesized that stress echocardiography may unmask the early non-invasive hemodynamic changes caused by chest wall rigidity and left heart involvement. Methods: A total of 72 participants were enrolled in the study: 26 had AS, 18 had PsA, and 28 healthy individuals were matched by age and sex. To assess the maximally tolerated workload, all subjects underwent resting and exercise stress echocardiography on a supine bicycle ergometer. Echocardiographic measurements were taken at rest, at 50 watts workload, and at maximal exercise. Detailed clinical characteristics were also assessed, including the advanced ankylotic axial status of both patient groups. Results: At rest, only pulmonary vascular resistance (PVR) values were significantly higher in patients with AS and PsA than in controls. During exercise, the tricuspid regurgitation velocity (TRV) was significantly increased in the AS and PsA groups. PVR stress was significantly higher in patients with AS and PsA than in controls. Discussion: Stress echocardiography is a promising method for assessing subclinical cardiopulmonary changes among AS and PsA patients. Changes in PVR during stress may highlight pulmonary complications related to chest wall restriction and remodeling of the pulmonary vasculature at the subclinical stage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.