ArticleFrontiers in medicine2025
Effect of single-injection thoracic paravertebral block with liposomal bupivacaine on the quality of recovery after thoracic surgery: a protocol for an open-label, randomized controlled trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Postoperative pain management plays a crucial role in determining the quality of recovery following thoracic surgery. However, achieving high-quality postoperative analgesia that facilitates satisfactory recovery remains challenging due to suboptimal pain control and side effects associated with conventional analgesic strategies. This study aims to evaluate the effect of single-injection thoracic paravertebral block with liposomal bupivacaine on the overall quality of recovery in patients undergoing thoracic surgery. Methods: This single-center, open-label, randomized controlled trial will enroll 162 patients scheduled for video-assisted thoracic surgery. Participants will be randomly allocated in a 1:1:1 ratio to three groups ( Discussion: This study aims to provide high-quality evidence on the efficacy of a single-injection thoracic paravertebral block with liposomal bupivacaine for post-thoracic surgery analgesia, compared with opioid-based intravenous analgesia alone and the combination of ropivacaine paravertebral block with systemic opioid analgesia. Clinical trial registration: Identifier: ChiCTR2500107787.
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