ArticleFrontiers in medicine2025
4D-CT strain analysis for biomechanical characterization of COPD in patients undergoing radiotherapy planning: an exploratory study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and altered pulmonary biomechanics. While conventional spirometry provides global functional information, it cannot assess regional heterogeneity. This exploratory study aimed to evaluate the diagnostic performance of four-dimensional computed tomography (4D-CT) strain analysis in differentiating normal lung function from COPD in a cohort of patients with small pulmonary lesions who underwent 4D-CT as part of radiotherapy planning, thereby establishing feasibility for potential future integration into treatment workflows. Methods: This single-center retrospective cross-sectional study included 46 patients with pulmonary lesions ≤ 3 cm who underwent 4D-CT localization scanning for radiotherapy planning between January 2021 and March 2024. Patients were stratified into normal lung function ( Results: Despite the small COPD sample size ( Conclusion: This exploratory study provides preliminary evidence that 4D-CT strain analysis, particularly Speedmax, shows promise for differentiating normal lung function from COPD in patients with small pulmonary lesions. However, given the small sample size and single-center design, diagnostic performance metrics should be interpreted with caution. External validation in larger, multi-center cohorts is required before clinical implementation.
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