ArticleFrontiers in immunology2025
Single-cell transcriptome-wide Mendelian randomization identifies mitochondrial targets in immune cells for Major Depressive Disorder.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study.Frontiers in genetics · 2026Article
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9 authors.
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Abstract
Background: A critical need exists for objective biomarkers and novel therapeutic targets in major depressive disorder (MDD). Although dysfunction in mitochondrial immunometabolism is implicated in MDD, the specific causal genes suitable for clinical translation remain largely unidentified. This study aimed to bridge this gap by identifying mitochondria-related genes that have a causal impact on MDD risk through their expression in specific immune cells. Methods: We integrated multi-omics data with machine learning to pinpoint key mitochondria-related energy metabolism genes (MEMRGs) linked to immune cell infiltration, assessed via ssGSEA and CIBERSORT algorithms. Cell-type-specific two-sample Mendelian randomization (MR) was employed to evaluate causal relationships between gene expression and MDD risk. Findings were validated in a chronic unpredictable mild stress (CUMS) rat model. Results: Our analysis identified five genes- Conclusion: This study provides robust genetic evidence establishing a causal link between the expression of specific mitochondrial genes in immune cells and the risk of MDD. By prioritizing
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