ArticleFrontiers in immunology2025
Immune checkpoint inhibitor-related Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective analysis of 21 cases.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions (SCARs) increasingly linked to immune checkpoint inhibitors (ICIs). Methods: We retrospectively analyzed 21 patients with ICI-related SJS/TEN treated at Zhongda Hospital, Southeast University, from 2019 to 2025. Results: The median latency from ICI initiation to onset was 28 days, most commonly following PD-1 inhibitors such as sintilimab and tislelizumab. Patients presented with diffuse erythema, blistering, erosions, and frequent mucosal involvement. All discontinued ICIs and received systemic corticosteroids; some additionally received intravenous immunoglobulin (IVIG). The mean time to re-epithelialization was about 10 days, and mortality reached 14.3%, limited to TEN cases. Conclusion: ICI-related SJS/TEN, though rare, represents a serious immune-related adverse event that requires prompt recognition and early immunosuppressive therapy. Increased awareness and further studies are needed to clarify its mechanisms and guide management. Based on our findings, we recommend heightened vigilance for early mucocutaneous symptoms in patients receiving ICIs, prompt dermatology referral for suspected cases, and establishment of standardized reporting pathways to national pharmacovigilance systems to ensure rapid identification and pooled analysis of ICI-related SJS/TEN cases.
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