ArticleFrontiers in aging neuroscience2025
A 24-week multi-component exercise program improves cognition and body composition in older adults with mild cognitive impairment: a randomized controlled trial.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Exercise, Sleep, and Cognitive Performance in Older Adults: A Structured Review of Mechanisms and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study investigated whether a 24-week, community-based multicomponent exercise intervention (MCEI) can improve body composition and cognitive function in older adults with mild cognitive impairment (MCI). Methods: In this single-center, parallel-group randomized controlled trial (RCT), 64 community-dwelling adults aged 65-75 years with MCI characterized by Mini-Mental State Examination (MMSE) ≥ 24, Montreal Cognitive Assessment (MoCA) ≤ 26, Clinical Dementia Rating (CDR) = 0.5, low skeletal muscle mass were randomly allocated (1:1) to a MCEI (aerobic, resistance and balance training, 3 × 60 min/week) or to a usual-activity control (UAC) group receiving weekly health education. Primary outcomes were skeletal muscle mass (SMM), fat-mass index (FMI), MMSE and MoCA; secondary outcomes included skeletal muscle index (SMI), basal metabolic rate (BMR), Instrumental Activities of Daily Living (IADL) and Animal Fluency Test (AFT). Assessments were conducted at baseline and within 1 week post-intervention by trained, blinded assessors. Intervention effects were examined with a 2 (group) × 2 (time) repeated-measures analysis of variance (ANOVA), reporting partial eta-squared (η Results: A significant Group × Time interaction was observed for SMM ( Conclusion: A 24-week community-based multicomponent exercise program safely increased skeletal muscle mass and reduced fat mass in older adults with MCI, but did not produce measurable improvements on screening-level cognitive measures. Future studies with longer duration, larger samples, and inclusion of cognitive challenges are warranted to clarify exercise-cognition interactions and establish dose-response relationships for both body composition and domain-specific cognition. Clinical trial registration: Identifier ChiCTR2000035012.
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