Evidence map›Paper›PMID 41601598›Full record

ArticleFrontiers in aging neuroscience2025

Association of psychosis with cognitive impairment is mediated by amyloidopathy in cognitive impairment.

Jung-Min Pyun, Sungjoo Han, Sang Won Park, Na Young Yeo, Young Ho Park, Sang Yun Kim, Young Chul Youn, Jae-Won Jang, and the Alzheimer’s Disease Neuroimaging Initiative

Abstract read
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In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jung-Min Pyun *Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea.
Sungjoo Han *Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
Sang Won ParkDepartment of Next Generation Big Data Center, Kangwon National University Hospital, Chuncheon, Republic of Korea.
Na Young YeoDepartment of Medical Bigdata Convergence, Kangwon National University, Chuncheon, Republic of Korea.
Young Ho ParkDepartment of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea.
Sang Yun KimDepartment of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea.
Young Chul YounDepartment of Neurology, Chung-Ang University Hospital, Seoul, Republic of Korea.
Jae-Won JangDepartment of Next Generation Big Data Center, Kangwon National University Hospital, Chuncheon, Republic of Korea.
and the Alzheimer’s Disease Neuroimaging Initiative

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Psychosis, including delusions and hallucinations, is a significant neuropsychiatric symptom in Alzheimer's disease (AD) associated with poor prognosis. The relationship between psychosis and AD pathology remains controversial. This study investigates the role of AD pathology in mediating the association between psychosis and cognitive impairment. Methods: Data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI). We included individuals with a Clinical Dementia Rating (CDR) score of 0.5 or higher. Among a total of 833 individuals, 96 individuals with psychosis were matched to 192 individuals without psychosis using propensity scores based on age, sex, education level, and follow-up duration. Baseline cognitive performance was assessed using composite memory scores (ADNI-MEM) and executive function scores (ADNI-EF). AD pathology was measured using baseline cerebralspinal fluid (CSF) levels of Results: Psychosis was significantly associated with worse ADNI MEM score ( Conclusion: These findings suggest that amyloid pathology may mediate the effect of baseline cognitive impairment on psychosis during disease in AD, highlighting a potential pathological link between cognitive decline and psychotic symptoms.

Indexed as

Alzheimer’s diseaseamyloidopathycerebrospinal fluidcognitionmediationneurodegenerationpsychosistauopathy

Identifiers

PMID41601598
PMCPMC12832791

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.