ArticleIBRO neuroscience reports2025
Neuroprotection and activation of anti-inflammatory and plasticity mechanisms by PLC-β inhibition after cholinergic hyperstimulation in hippocampal slices and microglial cells.
Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
Epilepsy, a chronic neurological disorder characterized by recurring seizures, involves inflammatory and abnormal plasticity features. Current treatments, primarily combinations of anticonvulsant drugs, often carry adverse effects, and a substantial portion of patients remain resistant to available therapies. In this study, we used the muscarinic agonist pilocarpine (Pilo) to probe epileptogenesis mechanisms and explore the effects of edelfosine (Ef), a synthetic alkyl-lysophospholipid (ALP), and phospholipase C (PLC)-β inhibitor, as a potential anti-epileptic agent. By targeting PLC-β activation, a link between muscarinic stimulation and brain injury, we assessed edelfosine's neuroprotective effects in an ex-vivo Pilo model. Ef, at 1 and 10 μM, significantly preserved neuronal PS in hippocampal slices compared to controls. Additionally, Ef (1 μM) in vitro studies demonstrated a reduction in proinflammatory gene expression, tumor necrosis factor-α (
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