ArticleIBRO neuroscience reports2025
The addictive and neurotoxicological evaluation of
Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Effects of Kalanchoe pinnata, exercise, and stimulation on neuroinflammation, redox homeostasis, and neuropathic pain in a Wistar-rat model.World journal of experimental medicine · 2026Article
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Authors and funding
3 authors.
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Abstract
Drug addiction is a relapsing and chronic brain disorder that is characterized by habitual, compulsive, and pathological patterns of substance seeking and usage despite the associated severe negative social and health consequences. Objective: This study evaluated the addictive and neurotoxicological evaluation of the alkaloid extracts of Results: The result established the addictive and neurotoxicological potentials of the alkaloid extracts via behavioral paradigms, coupled with inflammatory, monoaminergic, apoptotic, cholinergic, oxidative, and glutamatergic neurotransmission systems modulations. However, the observed neurotoxicity of the psychoactive plants' alkaloids was not directly proportional to their addictiveness as the psychoactive plants ranked CS > NT > DS > CM in addictiveness but ranked DS > NT > CS > CM for toxicological potentials, as measured using related behavioral, neurotransmitter, apoptotic and inflammatory systems. Conclusion: The toxicological effects of the psychoactive plants' alkaloids are mostly expressed at high doses.
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Registered trials
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