ArticleFrontiers in psychiatry2025
Comprehensive evaluation of the efficacy and patient acceptance of combined antidepressant and cognitive behavioral therapy in the treatment of post-traumatic stress disorder.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To improve treatment outcomes and enhance the prognosis of patients with PTSD (Post-Traumatic Stress Disorder), the efficacy and patient acceptance of antidepressant treatment for PTSD are comprehensively evaluated, and its clinical application value is explored. Methods: A retrospective study is conducted, with 200 patients divided into a medication group and a combination group, with 100 patients in each group. The medication group receives a single antidepressant (primarily a selective serotonin reuptake inhibitor) for 8 weeks, while the combination group receives the same medication plus a 60-minute weekly trauma-focused cognitive behavioral therapy (TF-CBT). Symptom severity, side effects, and adherence are assessed using standardized clinical interviews and self-rating scales. Correlation analysis and multiple linear regression (MLR) are used to explore the relationships between these indicators. Results: The combination group has higher medication satisfaction ( Conclusions: Compared with antidepressant monotherapy, combining antidepressant and CBT treatment significantly alleviates patient symptoms, reduces side effects, and improves treatment adherence and satisfaction. This study provides a new perspective for tailoring treatment plans and improving treatment precision and effectiveness.
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