ArticleFrontiers in bioinformatics2025
High-dimensional co-expression network analysis reveals persistent TRH gene expression throughout axolotl telencephalon regeneration.
Article in Frontiers in bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The Axolotl ( Results: We identified 180 hub genes across the regeneration timeline, including several with conserved orthologs previously reported in vertebrate regeneration models. Among these candidates, TRH (Thyrotropin-Releasing Hormone) displayed the most consistent spatiotemporal pattern, appearing repeatedly as a hub gene and localizing to MSN enriched regions at multiple stages. TRH is broadly characterized in vertebrates as a neuroendocrine peptide with roles in hormonal signaling, and MSNs are known to respond to a variety of hormonal and neuropeptidergic cues. In our dataset, this background provides additional perspective on the transcriptional configurations in which TRH appears. Other hub genes showed stage/cell specific patterns, together outlining a heterogeneous and dynamic landscape of transcriptional states detected during telencephalon regeneration. Conclusion: This study provides a descriptive map of gene co-expression dynamics during axolotl telencephalon regeneration. By integrating hdWGCNA, spatial transcriptomics, and network-based context, we identify hub genes and transcriptional states associated with injury response, including a persistent TRH linked MSN state. These findings offer a foundation for future experimental studies aimed at elucidating the molecular basis of axolotl brain repair.
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