ReviewBrain and behavior2026
Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling.
Review in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling.Brain and behavior · 2026Review
- The Versatile Roles of Exosomes in Neurodegenerative Disorders: From Pathological Mechanism and Diagnostic Biomarkers to Therapeutic Application.Drug design, development and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
aimsThe purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression during embryonic neurogenesis. It aims to highlight the role of these mechanisms in neural stem cell (NSC) fate specification and their implications in neurological and neurodevelopmental disorders.
methodsThrough reviewing recent research findings, this study synthesizes current literature on epigenetic mechanisms involved in embryonic brain development, with a focus on histone modifications, chromatin remodeling, and chromatin compartmentalization. The review also evaluates existing in vivo research while noting the technical challenges of tracking adult neurons and isolating NSCs.
findingsThe review identifies that epigenetic mechanisms, including histone methylation (notably H3K9 as a repressive mark), histone deacetylases, and chromatin remodeling complexes, play essential roles in regulating gene expression required for neurogenesis and neuroplasticity. Alterations in these epigenetic processes significantly affect neural development and contribute to a range of neurological and neurodevelopmental disorders.
conclusionsUnderstanding the epigenetic regulation of neurogenesis particularly through chromatin modification and structural chromatin dynamics provides valuable insight into cell fate determination during embryonic brain development. These insights may guide the development of novel therapeutic strategies for neurological and neurodevelopmental disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.