Evidence map›Paper›PMID 41601367›Full record

ArticleJournal of Zhejiang University. Science. B2025

PICK1 modulates the proliferation and migration of gastric cancer cells by regulating TLR4.

Kaiqiang Li, Yimin Yang, Yaling Wang, Jing Jin, Qianni Wang, Lina Peng, Aibo Xu, Xuling Luo, Wei Yang, Peng Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kaiqiang LiLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Yimin YangCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Yaling WangLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Jing JinLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Qianni WangLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Lina PengLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Aibo XuLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Xuling LuoCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Wei YangDepartment of Biophysics and Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Peng XuThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, China.
Bingyu ChenLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China. wangzhen@hmc.edu.cn, chenbingyu@hmc.edu.cn.
Ke HaoLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China. wangzhen@hmc.edu.cn, haoke@hmc.edu.cn.
Zhen WangLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China. wangzhen@hmc.edu.cn.

Funding

the National Natural Science Foundation of China 82172363the Traditional Chinese Medicine Scientific Research Project of Zhejiang Province 2023ZL010the Zhejiang Medical and Health Science and Technology Project 2022KY529 and 2024KY636
6 · The paper itself

Abstract

Protein interacting with C kinase 1 (PICK1) interacts with a variety of membrane proteins and receptors involved in nervous system diseases and multiple cancers. However, the role of PICK1 in gastric cancer remains unclear. In the present work, we explored the expression and interactions of PICK1 with Toll-like receptor 4 (TLR4) in gastric cancer. Clinical data analysis showed that PICK1 expression decreases and is predictive of worse outcomes in patients with gastric cancer. High PICK1 levels attenuate the proliferation and migration of gastric cancer cells, which is dependent on the TLR4/myeloid differentiation primary response 88 (MyD88) signaling pathway. Furthermore, in vitro experiments demonstrated that PICK1 affects the trafficking and degradation of TLR4 and promotes TLR4 degradation via autophagy in gastric cancer cells. Molecular dynamics simulations highlighted the binding strength and stability of the TLR4-PICK1 complex. Our study provides new insights into the cellular and pathological functions of PICK1 in gastric cancer.

Indexed as

Carrier ProteinsNuclear ProteinsStomach NeoplasmsToll-Like Receptor 4AutophagyCell Cycle ProteinsCell Line, TumorCell MovementCell ProliferationHumansMolecular Dynamics SimulationMyeloid Differentiation Factor 88Signal TransductionCarrier ProteinsCell Cycle ProteinsMYD88 protein, humanMyeloid Differentiation Factor 88Nuclear ProteinsPICk1 protein, humanTLR4 protein, humanToll-Like Receptor 4AutophagyGastric cancerMyeloid differentiation primary response 88 (MyD88) signaling pathwayProtein interacting with C kinase 1 (PICK1)Toll-like receptor 4 (TLR4)

Identifiers

PMID41601367
PMCPMC12848559

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.