Observational studyZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2026
[Efficacy of intravenous thrombolysis beyond 4.5 to 24 hours in patients with isolated posterior circulation acute ischemic stroke].
Observational study in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04487340 (Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the functional outcomes and safety of intravenous thrombolysis (IVT) administered within the standard 4.5-hour time window versus an extended time window of >4.5-24 h after symptom onset in patients with isolated posterior circulation acute ischemic stroke (AIS).
methodsData from patients with isolated posterior circulation AIS who received IVT between January 2017 and December 2024 were extracted from the Acute Stroke Patients for Stroke Management Quality Evaluation online database (CASE-Ⅱ, NCT04487340). Patients were categorized into the standard time window group (within 4.5-hour) and the extended time window group (>4.5-24 h). The primary outcome was 3-month functional independence (modified Rankin Scale score 0-2). Multivariate logistic regression and propensity score matching were used to compare outcomes. Interaction tests assessed the consistency of the time window effect across subgroups predefined by age, sex, baseline National Institutes of Health Stroke Scale (NIHSS) score, presence of large vessel occlusion, thrombolytic agent, and trial of ORG 10172 in acute stroke treatment (TOAST) subtype.
resultsAmong 3508 included patients, 3147 were in the standard time window group and 361 in the extended time window group. The rate of 3-month functional independence did not significantly differ between the two groups (80.1%
conclusionsFor patients with isolated posterior circulation AIS, IVT administered within >4.5-24 h after onset demonstrates effectiveness and safety comparable to treatment within the standard 4.5-hour time window.
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