Evidence map›Paper›PMID 41601286›Full record

ArticleBrain and behavior2026

Involvement of Adenosine A

Burçin Ün, Zeki Akarsakarya, Özlem Yorulmaz Özü, Nermin Seda Ilgaz, Mehmet Bertan Yılmaz, Deniz Seçilmiş, Mehmet Ata Seçilmiş

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In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Involvement of Adenosine ABrain and behavior · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Burçin ÜnDepartment of Addiction, Institute of Addiction and Forensic Sciences, Çukurova University, Adana, Turkey.
Zeki AkarsakaryaDepartment of Pharmacology, Medical Faculty, Çukurova University, Adana, Turkey.
Özlem Yorulmaz ÖzüDepartment of Pharmacology, Medical Faculty, Çukurova University, Adana, Turkey.
Nermin Seda IlgazDepartment of Medical Biology, Medical Faculty, Çukurova University, Adana, Turkey.
Mehmet Bertan YılmazDepartment of Medical Biology, Medical Faculty, Çukurova University, Adana, Turkey.
Deniz SeçilmişDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Mehmet Ata SeçilmişDepartment of Addiction, Institute of Addiction and Forensic Sciences, Çukurova University, Adana, Turkey.

Funding

Çukurova Üniversitesi TDK-2021-14114
6 · The paper itself

Abstract

backgroundPrevious studies have suggested that adenosinergic system in the central nervous system may play a role in both behavioral changes and the physiopathology induced by Δ

aimsIn this study, we aimed to investigate the possible role of the adenosinergic system in THC-treated mice.

methodsFor that purpose, we combined behavioral tests and molecular analyses to investigate the effects of THC in relation with the agonist and antagonist of the adenosinergic system, CGS-21680 (CGS) and istradefylline, respectively, on both anxiety-like behaviors and hippocampal gene expression.

resultsThe results demonstrated that THC induced anxiety-like behavior, and gene expression patterns indicated a significant interaction between the adenosinergic and cannabinoidergic systems. Notably, the data suggest that THC plays a predominant role in this molecular interplay, with its effects being partially modulated by changes in the expression of both cannabinoidergic and adenosinergic receptors, CB

conclusionThese findings contribute to the understanding of THC's complex pharmacological actions, highlighting the importance of receptor cross talk in modulating anxiety and other behavioral outcomes.

Indexed as

AnxietyBehavior, AnimalDronabinolReceptor, Adenosine A2AAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsAnimalsHippocampusMaleMicePhenethylaminesPurines2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsDronabinolistradefyllinePhenethylaminesPurinesReceptor, Adenosine A2Aadenosine A2A receptorsanxiety‐like behaviorshippocampustetrahydrocannabinol

Identifiers

PMID41601286
PMCPMC12848372

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.