ArticleAnnals of medicine2026
Pre-ablation stimulated thyroglobulin to TSH ratio as a strong predictor of non-generally satisfactory response to initial radioiodine therapy in papillary thyroid carcinoma patients undergoing lateral neck dissection.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Interpretable four-class machine learning prediction of initial I-131 therapy responses in differentiated thyroid cancer.Annals of medicine · 2026Article
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8 authors.
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Abstract
backgroundThe initial response to radioiodine (
methodsWe retrospectively analyzed 145 PTC patients who underwent therapeutic LND and initial ¹³¹I therapy. Clinicopathological characteristics, preablation stimulated thyroglobulin (Pre-sTg), thyroid-stimulating hormone (TSH) levels, and lymph node metastasis parameters were evaluated. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses identified predictors of n-GR at 6 months post-therapy.
resultsn-GR was observed in 24.2% (35/145) of patients. Multivariate analysis identified lateral neck metastasis burden (Odds Ratio [OR]: 1.026 per 1% increase, 95% Confidence Interval [CI]: 1.001-1.052,
conclusionIn our pilot study a Pre-sTg/TSH ratio > 0.127 significantly enhances risk stratification in PTC patients undergoing therapeutic LND when combined with ATA recurrence risk categories, supporting its potential use in personalizing treatment and follow-up strategies. Further validation in larger, multi-center cohorts is warranted.
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