Evidence map›Paper›PMID 41600880›Full record

ArticleViruses2026

Mental Health, Mucosal Immunity, and HIV Susceptibility Following Sexual Violence: Evidence from the THRIVE Study.

Katherine M Anderson, Eleanor Capozzi, Stephanie A Meyers-Pantele, Maile Y Karris, Fernando Cabezas Mejia, Ella Meyer, Melodie A Nasr, Mimi Ghosh, Jamila K Stockman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katherine M AndersonDepartment of Behavioral, Social, and Health Education Sciences, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-9675-3653
Eleanor CapozziDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Stephanie A Meyers-PanteleDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California, La Jolla, CA 92093, USA.ORCID 0000-0002-8564-0183
Maile Y KarrisDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California, La Jolla, CA 92093, USA.ORCID 0000-0001-5614-030X
Fernando Cabezas MejiaDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Ella MeyerDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Melodie A NasrDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Mimi GhoshDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0003-0029-9818
Jamila K StockmanDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California, La Jolla, CA 92093, USA.ORCID 0000-0003-1909-6965

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6M
Sexual trauma and HIV susceptibility among women: the role of stress and genital immunityR01AI128803 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, MIMI, STOCKMAN, JAMILA KINSHASA · 2017 to 2020
$2.4M
LOTUS: An mHealth Intervention to Improve HIV Prevention Service Engagement and Intersectional Stigma among Racially Diverse Women Who Use DrugsK01DA055983 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Stephanie Alice Meyers-Pantele · 2022 to 2026
$941k
National Institute of Allergy and Infectious Diseases R01AI128803NIAID NIH HHS P30 AI036214NIAID NIH HHS P30 AI117970NIAID NIH HHS R01 AI128803NIDA NIH HHS K01 DA055983
6 · The paper itself

Abstract

Sexual violence against women is a global issue with profound health consequences, including elevated HIV risk due to genital tract inflammation and injury. However, limited research has examined the influence of mental health on HIV-related immunity after violence. We analyzed longitudinal data from female survivors of past-month rape (N = 25) to explore associations between mental health (perceived stress, depression, post-traumatic stress disorder [PTSD], and resilience) and HIV-associated immune biomarkers in the female genital tract. In bivariate analyses, mental health improved over the three-month follow-up period. Immune biomarker levels remained largely stable, except for TNF-α and SLPI. At baseline, depression was significantly correlated with TNF-α, IL-6, and IL-1β. In regression analyses, depression was associated with TNF-α (β = -0.133 to -0.152) and IL-6 (β = -0.171 to -0.207). PTSD was significantly associated with IL-1α (β = 0.576 to 1.681). Depression and resilience were negatively associated with percent HIV inhibition in adjusted models. These findings suggest that depression and PTSD are associated with genital tract inflammation following sexual violence, which may compromise mucosal immunity and enhance HIV risk. This highlights the importance of integrated mental health and immunological care for survivors and the need for further research into psychoneuroimmune pathways influencing HIV risk after trauma.

Indexed as

HIV InfectionsImmunity, MucosalMental HealthSex OffensesAdultBiomarkersCytokinesDepressionDisease SusceptibilityFemaleHumansLongitudinal StudiesRapeStress Disorders, Post-TraumaticYoung AdultBiomarkersCytokinescisgender womenHIV preventioninflammationmental healthmucosal immunityrapesexual violence

Identifiers

PMID41600880
PMCPMC12846484

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.