Evidence map›Paper›PMID 41600834›Full record

ArticleViruses2026

Examination of In Vivo Mutations in VP4 (VP8*) of the Rotarix

Mauro França Silva, Beatriz Vieira da Silva, Emanuelle Ramalho, Yan Cardoso Pimenta, Leonardo Luiz Pimenta da Silva, Laricy da Silva Vieira, Maria da Penha Trindade Pinheiro Xavier, Alberto Ignacio Olivares Olivares, José Paulo Gagliardi Leite, Marcia Terezinha Baroni de Moraes

Abstract read
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mauro França SilvaProgram in Tropical Medicine, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21040-360, Brazil.
Beatriz Vieira da SilvaProgram in Tropical Medicine, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21040-360, Brazil.
Emanuelle RamalhoLaboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21040-360, Brazil.
Yan Cardoso PimentaProgram in Tropical Medicine, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0002-5000-9842
Leonardo Luiz Pimenta da SilvaLaboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21040-360, Brazil.
Laricy da Silva VieiraLaboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21040-360, Brazil.
Maria da Penha Trindade Pinheiro XavierLaboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21040-360, Brazil.
Alberto Ignacio Olivares OlivaresSecretaria Estadual de Saúde de Roraima, SESAU/RR, Rua Madrid, 180-Aeroporto, Boa Vista 69310-043, Brazil.
José Paulo Gagliardi LeiteLaboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0001-8663-3527
Marcia Terezinha Baroni de MoraesProgram in Tropical Medicine, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21040-360, Brazil.

Funding

CNPq CNPq, 310908/2020-5 fellowCNPq CNPq, 408463/2022-8Faperj FAPERJ, E26/210.701/2024Oswaldo Cruz Institute IOC/CNPq/PROEP 441653/2024-3
6 · The paper itself

Abstract

Group A rotaviruses (RVAs) remain the leading cause of acute gastroenteritis (AGE) in young children in low- and middle-income countries. In Brazil, the oral attenuated RVA vaccine (Rotarix

Indexed as

MutationRNA-Binding ProteinsRotavirusRotavirus InfectionsRotavirus VaccinesViral Nonstructural ProteinsVirus SheddingBrazilCapsid ProteinsChild, PreschoolFecesGastroenteritisGenotypeHumansInfantVaccines, AttenuatedCapsid ProteinsNS35 protein, rotavirusRIX4414 vaccineRNA-Binding ProteinsRotavirus VaccinesVaccines, AttenuatedViral Nonstructural ProteinsVP4 protein, Rotavirusacute gastroenteritisHisto Blood Group AntigenRotarix®Rotavirus A

Identifiers

PMID41600834
PMCPMC12846572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.