Evidence map›Paper›PMID 41600831›Full record

ArticleViruses2026

FMDV VP3 Induces IL-10 Expression in Porcine Macrophages via PI3K Interaction and PI3K/AKT-mTOR Pathway Activation.

Yuling Li, Zijing Guo, Yan Zhang, Li Luo, Chunsai He, Qiqi Xia, Jingyuan Zhang, Zhidong Zhang, Yanmin Li

Abstract read
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In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuling LiKey Laboratory of Animal Medicine of Sichuan Education Department, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Zijing GuoKey Laboratory of Animal Medicine of Sichuan Education Department, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.ORCID 0000-0002-2291-700X
Yan ZhangKey Laboratory of Animal Medicine of Sichuan Education Department, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Li LuoKey Laboratory of Animal Medicine of Sichuan Education Department, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Chunsai HeKey Laboratory of Animal Medicine of Sichuan Education Department, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Qiqi XiaKey Laboratory of Animal Medicine of Sichuan Education Department, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Jingyuan ZhangKey Laboratory of Animal Medicine of Sichuan Education Department, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Zhidong ZhangKey Laboratory of Animal Medicine of Sichuan Education Department, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.ORCID 0000-0002-2186-7661
Yanmin LiKey Laboratory of Animal Medicine of Sichuan Education Department, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foot-and-mouth disease virus (FMDV) infection elicits sustained, high-level interleukin-10 (IL-10) secretion in cattle and pigs, which correlates with lymphopenia and immunosuppression. We previously showed that macrophages are the principal source of IL-10 during FMDV infection in mice, but the viral trigger and host pathways remained unknown. In the present study, we examined whether the FMDV structural protein VP3 regulates IL-10 expression. To this end, a eukaryotic VP3 expression vector was transfected into porcine alveolar macrophages (3D4/21 cells), and IL-10 expression together with related signaling pathways was interrogated by qRT-PCR, ELISA, Western blot, co-immunoprecipitation (Co-IP), confocal microscopy, and luciferase reporter assays. The results showed that VP3 significantly increased IL-10 mRNA and protein levels (

Indexed as

Capsid ProteinsFoot-and-Mouth Disease VirusInterleukin-10MacrophagesMacrophages, AlveolarPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAnimalsCell LineFoot-and-Mouth DiseaseSignal TransductionSwineCapsid ProteinsInterleukin-10Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesFMDV VP3IL-10PI3K/AKT-mTOR pathway

Identifiers

PMID41600831
PMCPMC12846501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.