Evidence map›Paper›PMID 41600825›Full record

Observational studyViruses2025

Clinical Burden and Healthcare Utilization Associated with Hospitalizations of RSV-Infected Polish Children During the 2022/23 Season.

Jan Mazela, Teresa Jackowska, Marcin Czech, Ewa Helwich, Oliver Martyn, Pawel Aleksiejuk, Anna Smaga, Andrzej Tkacz, Joanna Glazewska, Jacek Wysocki

Abstract readObservational Study
In one paragraph

Observational study in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jan MazelaDepartment of Neonatology, Poznan University of Medical Sciences in Poznan, 60-535 Poznań, Poland.ORCID 0000-0001-9845-6759
Teresa JackowskaDepartment of Pediatrics, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.ORCID 0000-0003-0131-7854
Marcin CzechDepartment of Pharmacoeconomics, Hospital Infection Control Team, Institute of Mother and Child, 01-211 Warsaw, Poland.ORCID 0000-0001-7292-1712
Ewa HelwichDepartment of Neonatology and Neonatal Intensive Care, Institute of Mother and Child, 01-211 Warsaw, Poland.
Oliver MartynSanofi A/S, Vaccines Medical Affairs, DK-2100 København, Denmark.
Pawel AleksiejukSanofi Sp. z o. o., Vaccines Medical Affairs, 01-211 Warsaw, Poland.
Anna SmagaPEX Sp. z o. o., 02-796 Warsaw, Poland.ORCID 0000-0002-7585-6378
Andrzej TkaczPEX Sp. z o. o., 02-796 Warsaw, Poland.
Joanna GlazewskaPEX Sp. z o. o., 02-796 Warsaw, Poland.ORCID 0000-0002-8265-9727
Jacek WysockiDepartment of Preventive Medicine, Poznan University of Medical Sciences at Poznan, 61-701 Poznan, Poland.ORCID 0000-0002-5360-5826

Funding

Sanofi and AstraZeneca NA
6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract illness and hospitalizations in children aged ≤5 years worldwide. The aim of this study was to characterize the Polish population of patients aged ≤5 years who were hospitalized due to RSV infection, focusing on their clinical and epidemiological characteristics as well as treatment patterns.

methodsThis retrospective observational study was conducted between November 2023 and February 2024 in 41 hospitals with pediatric departments across Poland. Data from patients aged ≤5 years admitted due to RSV infection confirmed with antigen test or RT-PCR were collected. The dataset was weighted and extrapolated to allow conclusions applicable to the general population of patients aged 0-5 years hospitalized with RSV infection in Poland.

resultsData from 419 patients were analyzed. Over half (57.4%) were younger than 12 months, 84% were born at term, and 85.8% had no comorbidities. The most frequent manifestations of RSV infections were pneumonia (56.8%), bronchiolitis (35.9%), and bronchitis (12.4%). Viral co-infections were identified in 8% of patients. Regarding treatment, 21.1% of patients required respiratory support, 67.6% received inhaled steroid therapy, 61.5% were treated with antibiotics, 48.1% received beta2-mimetics and anticholinergics, and 44.3% underwent systemic steroid therapy.

conclusionsOur findings confirm that severe RSV primarily affects the youngest children with no comorbidities who do not present high risk conditions. To reduce the overall disease burden, preventive strategies should be offered to all children, not being limited to those in risk groups.

Indexed as

HospitalizationPatient Acceptance of Health CareRespiratory Syncytial Virus InfectionsChild, PreschoolCoinfectionCost of IllnessFemaleHumansInfantInfant, NewbornMalePolandRespiratory Syncytial Virus, HumanRetrospective StudiesSeasonschildrenepidemiologyinfectionpreventionrespiratory syncytial virusRSV

Identifiers

PMID41600825
PMCPMC12846529

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.