Evidence map›Paper›PMID 41600822›Full record

ArticleViruses2025

Transcriptomic and Epitranscriptomic Landscape of Integrated HTLV-1 in MT2 Cells.

Shuanglong Wei, Bohan Zhang, Jingwan Han, Hanping Li, Yongjian Liu, Lei Jia, Jingyun Li, Xiaotian Huang, Lin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuanglong WeiSchool of Public Health and Health Management, Gannan Medical University, Ganzhou 341000, China.
Bohan ZhangDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.ORCID 0009-0005-8152-6454
Jingwan HanDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Hanping LiDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Yongjian LiuDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Lei JiaDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.ORCID 0000-0003-3721-1998
Jingyun LiDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Xiaotian HuangSchool of Public Health and Health Management, Gannan Medical University, Ganzhou 341000, China.
Lin LiDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

Funding

National Natural Science Foundation of China 82473694
6 · The paper itself

Abstract

Human T-lymphotropic virus type 1 (HTLV-1), the first human retrovirus identified, is linked to adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. However, its post-transcriptional regulation remains poorly understood. Here, we used Oxford Nanopore direct RNA sequencing to profile the HTLV-1 transcriptome and epitranscriptome in MT2 cells. We identified 23 transcript isoforms, encompassing canonical and novel splice variants. Polyadenylation analysis revealed a predominant poly(A) tail length of around 50-100 nucleotides with transcript-specific variations. Distinct RNA modifications, including pseudouridine, N

Indexed as

Human T-lymphotropic virus 1TranscriptomeVirus IntegrationCell LineEpitranscriptomeEpitranscriptomicsGene Expression Regulation, ViralHumansPolyadenylationRNA MethylationRNA SplicingRNA, ViralRNA, ViralDRSHTLV-1modificationspolyadenylationsplice

Identifiers

PMID41600822
PMCPMC12846610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.