Evidence map›Paper›PMID 41600749›Full record

ArticleVeterinary sciences2026

Serum Lactate Dehydrogenase as a Biomarker of Disease Burden and Chemotherapy Response in Canine High-Grade Multicentric Lymphoma.

Rafael Costa Bitencourt, Marina Franc Garcia, Adilson Paulo Marchioni Cabral, Tatiana Geraissate Gorenstein, Jéssika Cristina Chagas Lesbon, Letícia Abrahão Anai, Heidge Fukumasu, Rodrigo Dos Santos Horta, Andrigo Barboza de Nardi, Aureo Evangelista Santana

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rafael Costa BitencourtDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane S/N-Vila Industrial, Jaboticabal 14884-900, SP, Brazil.ORCID 0000-0001-9432-1777
Marina Franc GarciaDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane S/N-Vila Industrial, Jaboticabal 14884-900, SP, Brazil.ORCID 0009-0006-8909-530X
Adilson Paulo Marchioni CabralDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane S/N-Vila Industrial, Jaboticabal 14884-900, SP, Brazil.ORCID 0000-0002-1725-8871
Tatiana Geraissate GorensteinDepartment of Veterinary Medicine and Surgery, Veterinary School, Universidade Federal de Minas Gerais (UFMG), Presidente Carlos Luz Avenue, 5162-Pampulha, Belo Horizonte 31310-250, MG, Brazil.ORCID 0000-0001-7033-6819
Jéssika Cristina Chagas LesbonSchool of Animal Science and Food Engineering, University of São Paulo (USP), Duque de Caxias Norte Street, 225, Pirassununga 13635-900, SP, Brazil.ORCID 0000-0001-9865-8983
Letícia Abrahão AnaiDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane S/N-Vila Industrial, Jaboticabal 14884-900, SP, Brazil.ORCID 0000-0002-7107-6032
Heidge FukumasuSchool of Animal Science and Food Engineering, University of São Paulo (USP), Duque de Caxias Norte Street, 225, Pirassununga 13635-900, SP, Brazil.ORCID 0000-0002-3265-5090
Rodrigo Dos Santos HortaDepartment of Veterinary Medicine and Surgery, Veterinary School, Universidade Federal de Minas Gerais (UFMG), Presidente Carlos Luz Avenue, 5162-Pampulha, Belo Horizonte 31310-250, MG, Brazil.ORCID 0000-0002-9885-4498
Andrigo Barboza de NardiDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane S/N-Vila Industrial, Jaboticabal 14884-900, SP, Brazil.ORCID 0000-0001-6463-2144
Aureo Evangelista SantanaDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane S/N-Vila Industrial, Jaboticabal 14884-900, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum lactate dehydrogenase (LDH) is a recognized prognostic biomarker in human lymphomas, yet its clinical significance in canine lymphoma remains insufficiently characterized. This study aimed to quantify serum LDH levels in healthy dogs and dogs with high-grade multicentric lymphoma (ML) (predominantly B-cell) and to investigate correlations between LDH levels and established clinical and laboratory prognostic indicators. Twenty-seven dogs were prospectively enrolled: healthy controls (G1, n = 7) and dogs with high-grade ML (G2, n = 20). Immunophenotyping was performed by immunohistochemistry (CD3/CD79a). LDH concentrations were measured at diagnosis (T0) and after six weeks of CHOP-based induction chemotherapy (T1). Statistical analyses included Kruskal-Wallis, Wilcoxon signed-rank, Pearson's correlation, and mixed-effects models. Dogs with high-grade ML exhibited significantly elevated LDH levels compared to controls (median 545.5 U/L, range: 288.2-2816 U/L vs. 143 U/L, range: 66-272;

Indexed as

B-cell lymphomabiomarkerchemotherapy responseCHOP protocolthrombocytopenia

Identifiers

PMID41600749
PMCPMC12846464

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.