Evidence map›Paper›PMID 41600636›Full record

ArticleToxics2026

The Protective Effect and Molecular Mechanism of Tetrandrine on Male Reproductive Damage Caused by Silicon Dioxide.

Hong-Mei Li, Xiao-Qi Zeng, Qing Chang, Yu-Xin Sheng, Ya-Jia Pu, Yi Wang, Bin Cheng, Hong-Hui Li, Jie Xuan, Ling Zhang and 1 more

Abstract read
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hong-Mei LiThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.
Xiao-Qi ZengThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.
Qing ChangThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.
Yu-Xin ShengThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.
Ya-Jia PuThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.
Yi WangThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.
Bin ChengThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.
Hong-Hui LiThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.
Jie XuanThe Fifth People's Hospital of the Ningxia Hui Autonomous Region, Shizuishan 753000, China.
Ling ZhangThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.
Hai-Ming XuThe Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China.ORCID 0000-0001-9170-000X

Funding

Director Fund of the Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University FP20240102Ningxia Medical University High-level Talent Project XT2023028Ningxia Medical University Interdisciplinary Disciplines JCXK2025002Ningxia Medical University Scientific Research Project XZ2024002 and FP20230103Ningxia Natural Science Foundation 2022AAC05027
6 · The paper itself

Abstract

The long-term inhalation of free silica dust causes silicosis-a prevalent occupational hazard-yet its systemic effect on male reproductive toxicity remains underexplored. Tetrandrine (Tet) is the only plant-derived anti-silicosis drug approved in China. This study investigates silica (SiO

Indexed as

antagonistic effectmale reproductive damagemolecular mechanismsilicon dioxidetetrandrine

Identifiers

PMID41600636
PMCPMC12846249

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.