ArticleToxics2025
Evaluation of Polystyrene Nanoplastics Induced Cardiotoxicity Under Different Dietary Patterns in Mice.
Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bacteria in bioremediation of metal waste-contaminated soils across sub-saharan Africa: mechanisms, driving factors, and efficiency.Biodegradation · 2026Pooled it
- Chronic fluoride exposure induces tissue damage, oxidative stress, and immune dysfunction in juvenile crucian carp (Carassius auratus).Fish physiology and biochemistry · 2026Article
- cGAS-STING signaling in pollution-induced toxicity: mechanism and relieving medication.Apoptosis : an international journal on programmed cell death · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNanoplastics (NPs), as emerging foodborne contaminants, can accumulate in the heart and induce toxic effects. However, whether NPs exert differential cardiac impacts depending on dietary habits remains unclear.
methodsIn this study, mice subjected to different dietary patterns (Normal diet, ND; High-fat diet, HFD; High-fructose diet, HFrD) were orally administered 80 nm polystyrene nanoplastics (PS-NPs) at a dose of 10 mg/(kg·day) for 1, 4, and 8 weeks. The fluorescence tracing, histopathological analysis, quantification of inflammatory and fibrotic markers, and transcriptomic sequencing were used to evaluate the distribution and hazardous effect of PS-NPs.
resultsBy the 8th week, significant fluorescence labeled PS-NPs accumulation was detected in the hearts of mice on HFD group and HFrD group. Histopathological and immunofluorescence analyses revealed that both HFD and HFrD groups exacerbated cardiac collagen deposition and inflammatory infiltration in PS-NP-exposed mice. Transcriptomic analysis further indicated that under HFD, PS-NP exposure primarily activated MAPK signaling pathway-mediated inflammation, thereby promoting fibrosis. In contrast, under HFrD, PS-NP80 amplified cardiac injury via the TNF signaling pathway.
conclusionsThese findings demonstrate that dietary habits can aggravate the cardiac toxicity induced by foodborne nanoplastics, highlighting the importance of considering dietary patterns in the risk assessment of food contaminants.
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Registered trials
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