Evidence map›Paper›PMID 41600580›Full record

ArticleToxics2025

Manganese Exposure Is Associated with Reduced Grip Strength: Evidence from Humans and Mice.

Peiyu Fang, Chuanqiao Tang, Shengtao Wei, Wenmin Lu, Shaohui Liu, Xiaoli Ma, Li'e Zhang, Guiqiang Liang, Jian Wang, Yang Peng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peiyu FangDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Chuanqiao TangDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Shengtao WeiDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Wenmin LuDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Shaohui LiuDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Xiaoli MaDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Li'e ZhangGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China.
Guiqiang LiangDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Jian WangGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China.
Yang PengGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China.ORCID 0000-0001-7733-6213
Yunfeng ZouDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although excessive manganese (Mn) exposure is known to cause neuromotor function in cases of poisoning, its effect on grip strength (a neuromotor marker) in older adults at environmental levels remains unclear. To investigate this issue, we conducted an integrated investigation combining epidemiology and animal experimentation to examine the association between urinary manganese and grip strength. A cross-sectional study of 375 elderly men (60-74 years) was conducted in Guangxi, China, from 2016 to 2017. Urinary Mn concentrations were determined by ICP-MS, and their associations with grip strength were evaluated using generalized linear models and restricted cubic splines. In parallel, 32 six-week-old male C57BL/6J mice were exposed to 0, 5, 10, or 15 mg/kg MnCl

Indexed as

C57BL/6J miceelderly mengrip strengthinflammatory cytokinesmanganese

Identifiers

PMID41600580
PMCPMC12846208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.