Evidence map›Paper›PMID 41600559›Full record

ArticleToxics2025

Insights into Transport Function of the Murine Organic Anion-Transporting Polypeptide OATP1B2 by Comparison with Its Rat and Human Orthologues.

Saskia Floerl, Annett Kuehne, Yohannes Hagos

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Saskia FloerlPortaCellTec Biosciences GmbH, Science Park Va, Marie-Curie-Straße 8, 37079 Göttingen, Germany.
Annett KuehnePortaCellTec Biosciences GmbH, Science Park Va, Marie-Curie-Straße 8, 37079 Göttingen, Germany.
Yohannes HagosPortaCellTec Biosciences GmbH, Science Park Va, Marie-Curie-Straße 8, 37079 Göttingen, Germany.ORCID 0009-0006-0207-0936

Funding

German Federal Ministry of Education and Research (BMBF) 03LW0709
6 · The paper itself

Abstract

Organic anion-transporting polypeptides (OATPs) are key transporters of hepatic uptake for endogenous compounds and xenobiotics. Human OATP1B1 and OATP1B3 are well-studied due to their role in drug-drug interactions. In contrast, data on murine OATP1B2, the rodent orthologue of these transporters, are limited, despite its importance in early drug development. Here, we systematically compared the transport characteristics of mouse and rat OATP1B2 under identical experimental conditions. The K

Indexed as

amprenavirclotrimazolecyclosporine AdrugshOATP1B1hOATP1B3ketoconazolemOATP1B2odevixibatolmesartanrifampicinritonavirrOATP1B2rosuvastatinSLCO1B1SLCO1B3species differences

Identifiers

PMID41600559
PMCPMC12846068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.