From Simplified Markers to Muscle Function: A Deep Learning Approach for Personalized Cervical Biomechanics Assessment Powered by Massive Musculoskeletal Simulation.

Accurate, subject-specific estimation of cervical muscle forces is a critical prerequisite for advancing spinal biomechanics and clinical diagnostics. However, this task remains challenging due to substantial inter-individual anatomical variability and the invasiveness of direct measurement techniques. In this study, we propose a novel data-driven biomechanical framework that addresses these limitations by integrating massive-scale personalized musculoskeletal simulations with an efficient Feedforward Neural Network (FNN) model. We generated an unprecedented dataset comprising one million personalized OpenSim cervical models, systematically varying key anthropometric parameters (neck length, shoulder width, head mass) to robustly capture human morphological diversity. A random subset was selected for inverse dynamics simulations to establish a comprehensive, physics-based training dataset. Subsequently, an FNN was trained to learn a robust, nonlinear mapping from non-invasive kinematic and anthropometric inputs to the forces of 72 cervical muscles. The model's accuracy was validated on a test set, achieving a coefficient of determination (R